You can try commenting those ip6 lines out but I doubt that would be the problem.
It is still possible that some applications can connect and others not depending on their settings and settings of your firewall (as chaley mentioned). I somehow assumed that you turned firewall off as the first thing and do not use a proxy but just to make sure - is this really the case?
If so, then I would simply try pinging status.calibre-ebook.com from command line as the next step (ping status.calibre-ebook.com)
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