In 1985 I moved to Atlanta, and was delighted to find a small shop called The Science Fiction & Mystery Book Store.
It was operated by two guys. One knew everything about one genre, and the other about the other.
It was a small shop, but they seemed to have everything in print for those two genres. That's all they sold. No books of any other type.
Assuming that the shop is in an appropriate location, I think that a mom & pop bookstore can succeed by matching Amazon's inventory of a particular subject. And Mom or Pop would have to be a knowledgeable enthusiast of that subject.
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