It seems to me that to use ADE, Amazon would have to either get a special interface from Adobe, or do some fancy manipulation behind the scenes, in order to make the licensing work without having to download to a computer first, and to keep the way licenses work (e.g. remove from one Kindle, and it frees up that license).
One of the selling points of a Kindle is that you don't have to have a computer to use it.
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