I've had numerous e-readers.. The first one supported .epub, because it was recommended here. I had trouble with ADE from the word 'go'... I wanted .epub, because the books I wanted only were in that format... Now they are all available for the kindle, anyway.
Then I bought my Kindle2i - never had any problems (apart from geo restrictions, which applies to any book from that publisher). I had dealt with Amazon before, and found them really good, fast to ship and a great customer service. Buying ebooks from Amazon is just one-click, and it's on your reader...
Because of all the talk of epub, I bought over a period of time a few, dedicated to that format.... Still had problems with ADE, and ended up selling them...
Then Sony 650 came out on special, and I just had to have it... Still had problems with ADE, but learned to strip the DRM...
I haven't read ONE book on the Sony, yet...
Amazon's marketing is smart... They don't get their bread and butter from selling Kindles, but from selling books...