Well, I've been looking at eReaders(primarily Nook and Sony) and played with a 350 at Best Buy yesterday.
I've been "sharing" my wife's Nook and we use the library a lot, so any eReader I purchase will have to support ePub. The Nook is ok, but I really like the 350, especially the pearl ink display with its responsive touch screen. And even though I only spent about 5 minutes with it, navigating through the various menus was very speedy, simple and straight forward. I love the physical size too, but like others have commented am concerned the screen might be a bit small for extended reading.
My wife definitely thinks it's too small and says I only want one because with all the page turns, it will seem like I'm making great progress through the books I'll be reading.
(I'm a very slow reader compared to her.....as she enjoys reminding me)