I always remove the class="calibre.." attributes from ePubs and then replace the stylesheet.css with my own, specifically tailored for a Sony PRS-300. You could try this and see if it helps - or just copy some of these styles as a test.
Note that all the font sizes are defined in EMs to scale according to the zoom level, (the PRS-300 only has S, M, L).
(To use this file in an ePub, rename the attachment to stylesheet.css).
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