Generally speaking, you will not be able to read a PDF formatted for an A4/Letter page on any device with a 6" screen. This is the "fault" of the PDF format, not the Reader; PDF is the worst possible choice for an e-Book format - it was not intended to be used for this purpose, and it's not at all good at it.
There are tools available to reformat PDFs for the Reader; they work by, for example, removing margins and chopping pages in half, but the results are very mixed.
If reading PDFs is your main reason for getting a reader, the only sensible choice at present is the iRex iLiad. It has a larger screen and does a pretty reasonable job of displaying PDFs without reformatting. It is, however, double the price of the Sony Reader.
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