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1) Depends on what type it is. B&N/eReader=easiest. iBooks=can't be done.
2) Sometimes, as .mobi format is … somewhat more lacking in the display department than epub. Also, KindleGen can introduce some really weird and annoying formatting errors, though Calibre might do better.
3) No. Dictionary, highlighting, text-to-speech etc. all work just the same.
Hope this helps.
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