I have found that using the standard Nook cable with my Computer my front USB connections often have this problem sometimes they will work and sometimes not, I'm not sure but it might have to do with the fact they do not provide enough power for the device, as the Nook cable tries to pull the Full 500ma from the port. I know when I have other device plugged in to the 2nd front port 100% of the time the nook will not be recognized correctly, I take that 2nd load off the port tho and I find it get better results, I have resorted to using my back usb straight off the mobo as those provide full power all the time.
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