I recently flew from IAD to LGA in the middle of a good book. I really didn't want to put it down. But, having just got my ASEL (October 9, woohoo!!), I know I want my instructions to be followed when I'm PIC, so I turned it off.
It sucked, but coming home was very much worth it. We turned across Manhattan just after dark, and the view was incredible. It was kind of like a candy cane, one street all red (tail lights), the next all white (headlights).
I don't think the reader would cause much of a problem since it "off" most of the time, but still, you have to follow the flight crew's instructions as per federal regulations.