Maybe you need a newer version of calibre. I recently received a sony PRS 650 for my birthday to replace my 600 (which I'm gifting for Christmas). I loaded all my books onto a thumb drive but had the above problem when I went to load them onto my new device, that is, no device listed. It was plugged in. I still had 6.28 calibre loaded. Once I loaded the newest version, it recognized my reader.
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