If it is straight text, you shouldn't have a problem. The small-screen ereaders (5" & 6" ones), I've found, don't really do that well when there are a lot of graphics in the PDF's. The screens are too small and you have to do a lot of zooming. They seem to take longer to load, too.
The 350 does have five different page modes: Original, Margin Cut, 2-Column Split, 3-Column Split, and Full Page, which helps to make things easier. And it does have PDF reflow capability. I assume that the 650 has the same modes.
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