Left handed with a K3 here. No problems. I don't use the toggle much so it's not really an issue. Then again, I played guitar for 17 years and since I played lefty guitars my right hand was my fretting hand (odd, I know) so it did the really intricate stuff, and as I shoot with DSLR's my right hand does the shutter firing. Maybe those two things help even though I truly am left hand dominant.
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