I think this post proves that many lefties can use the Kindle very well but I do sympathize that, for the OP, being a left-hander caused such an issue with using the Kindle that it had to be taken back. I hope you find something which works for you OP.
Luckily I'm ambidextrous (from a leftie family but forced to write with my right hand at school) and can hold the Kindle in either hand. The positioning of the 5-way controller is a little awkward when holding the Kindle in my left hand but once reading a book, I'm mostly just using the page turn buttons which are easy for either hand.
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