I have a case (Macally) that protects the back and sides of the iPad. You can press the buttons through the case (although they're a bit stiffer than when there's no case), but the orientation lock is recessed. It can be accessed, but it's not as easy as without the case, especially when I've just clipped my nails. I like the extra protection the case adds, since I'm paranoid about damaging the iPad and put a scratch in one corner within a week of buying the iPad (which is what led to the case), so I don't want to do without it, but the recessed orientation lock switch has been the biggest down side.
So I'm really looking forward to the software option in iOS 4.2. I can see where many people don't see re-purposing it to a mute switch as a positive move, and maybe it isn't, but I look forward to not having to deal with that switch every time I want to lock the rotation.
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