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One thing to keep in mind here is that it's not simply the font or size that impacts eyes and can create eyestrain. When you read, your eyes go back and forth on a page, minutely examining words and lines of text. If your eye has trouble discerning text or words, it will spend more time examining them, jumping back and forth over every word, every letter. This is muscle movement, and too much of it causes strain.
Lack of contrast, and even too much contrast, can cause eyes to work overtime as well. Eyes sometimes have to examine a view, then shift slightly to check its first findings against another sample. Overly-small fonts of any type can also cause that.
Basically, any combination of font size, background color, brightness and contrast that allows your eyes to read while minimizing movement, will minimize eyestrain. And since everyone's eyes are different, everyone needs different combinations to reach their optimum viewing state. Overall, the more you can control these things, the better off you'll be.
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