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For what it's worth, I'm a professional programmer, so I sit in front of a screen all day, and I spent a lot of my non-work time in front of one as well.
That said, I find intensive textual reading on an LCD or CRT to be extremely taxing. When I'm working, I have to take breaks every hour or two to allow my eyes to recover. E-ink doesn't have that problem.
From talking to other people, I don't think I'm in the minority in finding that extended on-screen reading causes serious eyestrain.
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