I have a Kobo, and don't find the page turn button a problem at all. Some left-handed people don't like where it's placed, but I can't imagine why handed-ness is an issue (I am of course right-handed). I find it's a natural for my thumb, but I guess I would just hold it with my right hand and turn with my left were they reversed.
I only have around 200 books, but found browsing books much easier when I discovered the letter menu at the top of the screen (only took 2 months - doh!)
I'm very happy with my Kobo 1; don't have the WiFi version but will look closely to see if I want to upgrade.
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