Something I came across that others might, I was trying to edit metadata by downloading. But to Download I needed to get the ISBN from inside the file so I opened it *and left it open* doh!! .. then after metadata successfully downloads and I go to click Ok I get permission denied (because its trying to move the file to a new title folder but the file is still open in acrobat).
I know this is really dumb, but nevertheless ... it might help someone else