A few comments: I've never used a Kindle but the nook's weight seems fine to me; never felt that it was too heavy to read with at all. The touch-screen is a little fussy, but what isn't? And it does wash out in bright sun. Not to the point of being unusable, but it is an LCD and not e-ink, after all.
The web browser is not great; it's good for checking simple sites and handles mobile sites (like m.cnn.com) well. It kind of chokes on the B&N site, ironically.
My impression is that the Kindle 3 is probably a more refined piece of hardware, but I wanted library epubs and that lead me to the nook. That being said, I think the nook is very good with no more quirks or annoyances than this Windows XP laptop on which I am typing.