I'm fine with UK spellings when I read. I actually enjoy thinking about the little variations in the written language, but I can be a little nerdy about words. I find it hard to imagine that someone, who was otherwise enjoying your writing, would be upset if someone "labours" instead of "labors." Some readers are even bright enough to know that regional spelling variations exist.
I suppose some people might think you spelled something wrong, but if they bother to look it up in a dictionary, they will likely see the spelling variations.
Actually, I've never been able to figure out why publishers would even go through the bother of changing UK and American spellings for regional editions. Would it kill an American kid to be exposed to a UK spelling when he or she is reading Harry Potter?
People in the UK have purchased my novels and I've never had a complaint about my American spellings. After all, I am an American. I also went to journalism school in California where British spellings and usages are religiously stamped out of writing just because out West you are pure Americans without any taint of the Old World upon you (like what happens to Easterners).
I suppose I'll stop before I upset every region of the English speaking world.
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