I have both and love both. But if it was my only reader then I would probably go for the 650 as the size is better for long term reading, at least for me.
The 350 is amazing, and I would not be without it, but I bought mine to keep in my handbag, so its my portable one, holding whatever books I am currently reading on my main readers. It is super cute and really dinky, so perfect for travelling. It feels so much smaller than the 300 too, not that it was big, this just feels nicer, so slim and comfortable to hold. The fonts on the 350 are so crisp and easy to read, so that is really not an issue, I can read easily on the 350 and I do wear glasses for reading, but can read without them the fonts are so clear, plus at a smaller font that Im used to. I find the pearl screens so clear that I have changed to smaller fonts on my Kindle 3, 650 and 350. It may be smaller than the 300 but it is far easier to read on.
I just think I prefer my main readers to be closer to paperback sized, it is what Im used to. But I won't be giving up my 350 any time soon, love it too.
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