If the book was bought/downloaded from Barnes & Noble, then you should contact B&N with the issue. Hopefully they will alert the publisher of the ebook and (maybe) get a new version up.
The problem is with the ebook in question, not so much the nook itself (probably). Either an incorrect encoding was used somewhere during the book's creation (in which case there may be ?'s where emdashes and the like should be), or the ebook include special characters that don't exist in the nook's font (in which case the ?'s will happen within words)..
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