Ebook readers generally can't justify the text in PDFs, and how much they can do with them (reflow or zoom) depends a lot on how the PDF was made. A Kindle DX might work, depending on the size of text in the original, and whether you need color.
If you need to read letter-sized PDFs, your best option is probably either a netbook or tablet like the iPad, which doesn't need to resize them to make them readable. The other option is to convert to something like HTML or RTF, and then reformat the converted document to ungarble it & re-arrange the pictures.
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