Marie--
Be aware that different books can display different size fonts for each size--depending on how the publishers set the book up. I have one book on my nook that I need to set the font to "large" in order to read comfortably. Most books, I set at "small"--and bump it up to medium when I'm tired.
If the books don't have DRM, you should be able to change the default font size in Calibre. I haven't really experimented with this yet--but there are settings to make the font size bigger or smaller when converting.
dordale