I've never had uninstall first since I didn't start calibre until after the major shift that required it (0.6.17 in Windows). I always download and save the installation file to a temporary folder on my desktop, then just make sure calibre isn't running before I run the installation file. I haven't had any problems doing that. Also, I save all my most recent installation files (same as do for all downloaded programs) in case a fatal bug crops up and I have to regress a version. So far, with upgrades coming roughly a week apart and the rare bugs being fixed in that timeframe (ain't no other program that does that; thanks, Kovid!), I've never had to do that.
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