LRF tends to have some of the same problems mobi has with dropcaps and I know if you have a an italics tag before a comma in the LRF version the italics tag adds a space in the next so you'll get something like "example , sentence here" on your screen. It's mostly noticeable at the end of sentences or anywhere there is punctuation. In epub this does not happen.
But I still use LRF because I like the full justification and there are no page numbers on the side of my screen which tend to overlap the text, which I find far more annoying than spaces before punctuation when there is italicized text.
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