As an engineer I have similar requirements. For the last 4 years I have been using a tablet PC with the Microsoft OneNote application as a replacement for my paper notebooks and have not used any paper in that time. I can thoroughly recommend OneNote for annotation and notetaking.
I now need to replace my tablet but see no alternative yet to tablet + ereader. The Entourage Edge looks an interesting step but needs some refining. In the meantime I will get a Windows 7 tablet pc or slate and a large format ereader, possibly the ASUS 950 if it is ever released.
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