On that issue I found the way to set the iTunesArtwork as a
proper cover.
Edit the content OPF file and set
Code:
<meta name="cover" content="iTunesArtwork"/>
<manifest>
...................
<item href="iTunesArtwork" id="iTunesArtwork" media-type="image/jpeg"/>
............
Obviously I am not going to do all my library by hand but if Calibre does not add any friendly option in this regard

I think I might try to write some script to unpack, modify and repack the EPUBs.
I don't give up easily on my modifications
Even better would be rename the iTunesArtwork to cover.jpg|png and add the semantics as needed.