I have arthritis in my fingers and they get cramped up all the time. I don't have this problem with the Nook. I usually use the page swipe, but sometimes I use the buttons. Now just because it doesn't bother me doesn't mean it won't bother you. You could always try a Nook and then return it withing the 14 days if you don't like it. Then you can order the Kindle if the Nook doesn't work out.
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