Connect your nook to your pc via the usb cable. Open the nook folder, drag and drop your book to the "My Documents" folder under the Nook. Right click and "eject" the nook, unplug it and then check for new content.
Note - this works for non-drm content. If it is an ebook with a drm, you may have to install Adobe Digital Editions and load it through that.
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