All DRM sales lock you in to that DRM mechanism - so Amazon locks you into their DRM, those using Adobe with ePub lock you into theirs, and Apple locks you into their different ePub scheme. IIRC, there's a difference with Nook ePubs too.
The only thing that's more open about the Adobe DRM is that multiple vendors use it, so others could potentially join in.
Where content has no DRM, there's no lock-in. So all readers can read content from Smashwords, Baen etc.
My main peeve is limited access to content, in which DRM plays a significant role.
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