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I would go with the Kindle DX Graphite model. If you don't mind waiting, there will be better devices late this year or early next year. I am a scientist and I read a lot of textbooks. I have tried multiple 6" readers and they just won't do. You definitely need the larger screen for textbooks and technical content in PDF. I have tried many devices.
iPad has the best PDF support I have seen yet with the shortcoming of the LCD screen if it causes you eye strain. The Kindle DX is decent but not even close to the iPad as far as support for PDF. Have not tried the Graphite yet but I have heard there are improvements. The Entourage eDGe is not bad but it is heavy and not an ideal ebook reader. However, it does support annotations on PDF.
Unless you have an immediate need for an e-reader, I would suggest that you wait for a few months to see what becomes available. In the meantime, you can continue to read on the iPad. For medical books, you might need the color support for Anatomy textbooks, etc. If you don't want to wait and must get an e-reader now, the Kindle DXG seems the best given the lack of other options. The Kindle 2 or Kindle 3 when it comes out (provided it's only 6") would not be a good choice for textbooks unless they are formatted specifically for that screen size.
Of course, this is all a matter of opinion and based on my own experience.
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