I don't have a script, it's a manual editing process which takes about 30-60 minutes per book, irrespective of the number of pages. For complex fixed layouts you are better off with PDF than EPUB although arbitrary white space can be preserved in text files by using markdown. Sounds like you need a reader with an A5/A4 screen size and full PDF capability built in. (Maybe the manufacturers have these in the pipeline.) My PRS-300 renders PDFs very well but it's a bit slow and viewing a whole page at a time makes the text almost too small to read.
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