I would like to nominate
"The Brief Wondrous Life of Oscar Wao" by the Dominican author Junot Díaz.
A short summary (from wikipedia.org):
The novel is narrated by Yunior de Las Casas and Lola de Leon and chronicles both the life of Oscar de Leon, an overweight Dominican boy growing up in Paterson, New Jersey who is obsessed with science fiction and fantasy novels and with falling in love, as well as the curse that has plagued his family for generations.
The middle sections of the novel center on the lives of Oscar's runaway sister, Lola; his mother, Hypatia Belicia Cabral; and his grandfather, Abelard. Rife with footnotes, science fiction and fantasy references, comic book analogies, and various Spanish dialects, the novel is also a meditation on story-telling, the Dominican diaspora and identity, masculinity, and oppression.