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As brainycat said, you can install any font you wish on PocketBook. For non-DRM protected books you can set any font (including other type of fonts than ttf), set any size you wish.
If you install third-party version of fbreader you can also fine tune the format of the book - justification, hyphenation, line spacing, margins, first line intend, paragraph spacing, bold font by default, ... just about anything.
BUT.
If I was to recommend a book reader for a legally blind person, I would probably suggest the new Kindle DX graphite.
It has large display, which is VERY important if you need really large font size, so you do not have to turn page that often. Plus, it has better contrast than other readers. The fact it uses default font that is not very well suited for such reading isn't that important, because with [almost] any reader out there you can always prepare pdf file with the desired layout.
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