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Not really. The current pdf engine doesn't support multi-column. A new pdf engine is in the works that will support multi-column. You can access it today via the command line by using the ebook-convert command with the argument --new-pdf-engine. It won't fully convert the book, but it will turn a multi-column pdf into a single column html file if you also specify a debug output location using the -v argument.
That said the html file it produces today is pretty rough and will definitely need further editing - it may not be worth it to you.
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