It seems counter-intuitive, but I just tried reading for a while in landscape and I think I like it. I find reading with the cover a little awkward (the device is so much heavier than the cover that holding it like a p-book makes the corner dig into my hand) and there's no great place to put your hands without it.
Is it just me, or is the font bigger in landscape? I had to make it smaller when I switched and I never read with it on the smallest font. It does work out great - when I hold it in my left hand my thumb naturally rests on the page advance button.
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