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Calibre is not a trojan and does not have a virus.
Give your problems, I would have to guess that there is something wrong with your computer. I've run Calibre on three different computers and no problems at all.
The issue you've reported is not an issue. It's not a problem. In fact, if there is an antivirus interaction, it's the fault of the antivirus program.
As for Calibre running slow, have you tried running it with nothing else running?
What are your computer specifications? Have you made sure you don't have a virus causing the problems?
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