I'm a Kindle owner/e-Ink lover (enthusiast?) I've owned 4 different e-ink devices over the years, and I have always been in the camp that feels there is less eyestrain with an e-ink device because there is no refreshing or backlight.
Well, I decided that I'd try an experiment. I easily spend about 6-8 hours in front of 2 LCD screens every weekday, and I tend to get eyestrain by the end of the day. I've lowered the brightness on my monitors, and moved my primary monitor from about 24 inches away from my eyes to about 12 inches away from my eyes. We'll see how it goes.
Let the Great Experiment BEGIN!!!