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You say it's a Dell Inspiron 8400 desktop? In looking at Dell's support area for drivers the only 8400 desktop I come up with that has that model number is a Dimension (not Inspiron) is that your model? (is it a P4 machine)
The only things I can think of trying are making sure the BIOS and Chipset drivers are the most recent. That or trying a separate USB card.
You said you tried the reset button. I'm assuming you mean the slider on the Kindle and that you did in fact actually reset it. (that's been a solution for some folks USB problems)
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