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What's this system going to be used for and why would you want 4-5 hard drives in a system?
I rarely upgrade a system over time; unless I know that I can use the old parts in another system. Instead I'll often donate it or hand it off to a relative who's fried their ancient system.
As for changing out cases... yes it's doable, but not always a great idea; pray that it's not a custom case and you don't break anything. I've done it a few times. The last time was for a dual socket rendering system at work that was overheating & far too loud; new case, fans and heatsinks. It was a severe PITA.
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