I hope it's alright to bump this thread. I have been developing a hobby comic project using Sigil (available for both Windows, OS X and Linux). It's completely free, the only thing you need is knowledge of HTML/CSS. Otherwise Pages is a good bet.
I have not however managed to get acceptable results with fullscreen images without tearing/splitting up pages and other side effects. In Stanza you can get a pretty good reading experience with nice swipes from page to page. You can set a cool background to fill out the parts the page itself does not.
Anywho. My 2 cents.
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