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Another idea I got from Thoughcrime Experiments and from forum user pepak is use emphasis tags to make text regular typeface instead of italics.

I was working on a copy of Enter Without Desire by Ed Lacy that I downloaded from Munsey's, and there is a preface which is shown italicized, and then there is a word here and there which is shown in regular typeface for emphasis.

What I originally did was something like:

<em>...blah blah blah...</em>emphasized words<em>...blah blah blah...</em>

Which works but is very inelegant from the point of marking up text semantically.

If you put in some CSS that looks like this:

.preface {
    font-style: italic;
}

.preface em {
    font-style: normal;
}

then you can instead write:

<div class="preface">...blah blah blah...<em>emphasized word</em>...blah blah blah...</div>

which is a lot more satisfying.