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InDesign's strengths lie in its page layout tools, which can't be beaten, but are largely irrelevant for reflowable content. There are certainly a lot of alternatives that are far cheaper and more suitable for ePubs. As Toxaris said, Word or similar programs like Atlantis or OpenOffice that can export xml are a good place to start, and offer a richer set of tools for text creation.
It's certainly possible to create an ePub entirely in Sigil. But it's really designed as an editor, and to get the most out of it you need to understand how xhtml and css works.
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