Well, you'll definitely want to embed fonts if you plan to try to use ligatures.
To test, I created a one-line text (utf8) file:
Code:
My affinity for fish offends floridians.
And converted with calibre to ePub. (The embedded HTML it creates includes the same characters, again with utf8 encoding.)
Calibre's viewer at least showed all the right characters, and the fi and fl ligatures look good, but the ff and ffi ligatures were rendered in a different font. Not exactly a step towards more professional output!
But that's better than what ADE did with it:
Here the ff and ffi ligatures were completely missing. (I'd imagine that ffl wouldn't work either. I should have made the floridians affluent, I guess.)
And yeah, searchability broken. I was kind of hopeful that ADE would be smart about this, since Adobe Acrobat and Reader can "see through" ligatures when doing search (as can most PDF software, from what I've seen), ADE certainly can't. Hopefully that'll change.