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weird. i run mine in windows 7 64 bit professional and have never had a problem, seriously. i've never set compatibility modes either. it launches fast and runs just fine, i can download books from sony, upload books to my reader, and check out adept protected books from my library.
maybe all the tweaking has thrown a monkey wrench into other people's installations? try removing the software entirely and reinstalling and see where you go from there?
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