2.2.1 got a real cropping feature for pdf with manual cropping of white margins for even and odd pages.
higher responsivness for the stylus - for handwriting and textmarking and real faster but still not realtime erasing
and higher responsivness for stylus menu navigation
A SONY T1 word looking mode style - hold the stylus direct on a word and you are able to looking for it in the dictionary or google or wikipedia i use it very often
the contrast for pdf in adobe viewer seems to be improved
the adobe viewer is now able to read epub with and without DRM and got similar functionalty in epub-mode than the FBReader and renders some epubs better than FBReader.
The TextToSpeech is improved - the reading flow is definitely smoother - not such long pause after punctuation in former versions.
but 2.2.1 is in alpha mode which means there has to be some major bugs to resolve and meanwhile are mentioned to be fixed in the beta version which is not released yet in the bug tracker i am looking for!