If you have used a table or various sizes of pictures, fancy drop caps or embedded fonts, it will become clear why Sigil is good only up to a certain point. Beyond that, it will need to be viewed in ADE or one of the viewer programs or a device.
Beyond that you will need to use epubcheck if it has footnotes because Flight Crew does NOT catch footnotes that aren't attached to a corresponding item, only duplicated ones.
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