I think PonMan meant emailing the APK to your eDGe in order to install and test run it - the way QA's do their testing.

But as a Windows developer I like having the integrated debugger working in my Visual Studio so that I can trace through lines of code to see where a value changes or where and why an exception is thrown. From my understanding, the adb connection effectively allows a developer to remotely debug their app in context. Disconnected testing certainly works, but you have to throw in debug lines to log or popup info, then you have to correct the code, recompile, redeploy, and start again. That's why an adb connection is preferrable

Maybe if you set it aside for a day and come back to it, you may find what's knocking out the adb connection.